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KMID : 0892920090180020123
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Experimental Neurobiology
2009 Volume.18 No. 2 p.123 ~ p.128
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Neuroprotective Effect of Fucoidan against N-methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampus
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Ha Young-Joon
Kim Youn-Sub
Lee Hye-Jung
Seo Jin-Hee
Sung Yun-Hee
Kim Sung-Eun
Shin Mal-Soon
Kim Chang-Ju
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Abstract
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Fucoidan, a sulfated polyanionic polymer of L-fucose, is obtained from brown marine macroalgae. In the present study, neuroprotective effect of fucoidan against N-methyl- D-aspartate (NMDA)-induced excitotoxicity in the hippocampus was investigated. The patch clamp study revealed that fucoidan significantly inhibited NMDA receptor-activated ion current in the acutely dissociated hippocampal CA1 neurons. In an organotypic hippocampal slice culture, fucoidan inhibited NMDA-induced neuronal cell death in a dose-dependent manner. The present study showed that fucoidan possesses a neuroprotective effect against NMDA-induced excitotoxicity, and that the suppressive effect of fucoidan on the NMDA-induced ion current can be suggested as being the underlying neuroprotective mechanism of fucoidan.
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KEYWORD
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fucoidan, N-methyl-D-aspartate, hippocampus, patch clamp, slice culture
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